Quantitative systems pharmacology modeling of tumor heterogeneity in response to BH3‐mimetics using virtual tumors calibrated with cell viability assays

• Prif Awduron: Thibaud Derippe (Awdur), Sylvain Fouliard (Awdur), Xavier Decleves (Awdur), Donald E. Mager (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Wiley, 2024-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Both primary and acquired resistance mechanisms that involve intra‐tumoral cell heterogeneity limit the use of BH3‐mimetics to trigger tumor cell apoptosis. This article proposes a new quantitative systems pharmacology (QSP)‐based methodology in which cell viability assays are used to calib...