Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

• Asıl Yazarlar: Liana Cerioni (Yazar), Andrea Guidarelli (Yazar), Mara Fiorani (Yazar), Orazio Cantoni (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We investigated the effects of prostaglandin E2 (PGE2), an important inflammatory lipid mediator, on the cytotoxicity-genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO2−.) formation, PGE2 promoted conditions...