Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

• Hoofdauteurs: Liana Cerioni (Auteur), Andrea Guidarelli (Auteur), Mara Fiorani (Auteur), Orazio Cantoni (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We investigated the effects of prostaglandin E2 (PGE2), an important inflammatory lipid mediator, on the cytotoxicity-genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO2−.) formation, PGE2 promoted conditions...