Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma

• 主要な著者: Joaquín Yanes-Díaz (著者), Raquel Palao-Suay (著者), María Rosa Aguilar (著者), Juan Ignacio Riestra-Ayora (著者), Antonio Ferruelo-Alonso (著者), Luis Rojo del Olmo (著者), Blanca Vázquez-Lasa (著者), Ricardo Sanz-Fernández (著者), Carolina Sánchez-Rodríguez (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Currently, new treatments are required to supplement the current standard of care for head and neck squamous cell carcinoma (HNSCC). The phosphatidylinositol3-kinase (PI3K) signaling pathway is commonly altered and activated in HNSCC. PHT-427 is a dual PI3K-mammalian target of the AKT/PDK1 inhibitor...