Development, Characterization and In Vivo Pharmacokinetic Assessment of Rectal Suppositories Containing Combination Antiretroviral Drugs for HIV Prevention

• Main Authors: Kunal Jhunjhunwala (Author), Charles W. Dobard (Author), Sunita Sharma (Author), Natalia Makarova (Author), Angela Holder (Author), Chuong Dinh (Author), James Mitchell (Author), Lin Wang (Author), Junmei Zhang (Author), Sravan Kumar Patel (Author), Walid Heneine (Author), Lisa C. Rohan (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Receptive anal intercourse (RAI) contributes significantly to HIV acquisition underscoring the need to develop HIV prevention options for populations engaging in RAI practices. We explored the feasibility of formulating rectal suppositories with potent antiviral drugs for on-demand use. A fixed-dose...