Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes

• Main Authors: Tony Le Gall (Author), Mathieu Berchel (Author), Lee Davies (Author), Angélique Mottais (Author), Rosy Ghanem (Author), Alain Fautrel (Author), Deborah Gill (Author), Steve Hyde (Author), Pierre Lehn (Author), Jean-Marie Lehn (Author), Loïc Lemiègre (Author), Thierry Benvegnu (Author), Paul-Alain Jaffrès (Author), Bruno Pitard (Author), Tristan Montier (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aerosol lung gene therapy using non-viral delivery systems represents a credible therapeutic strategy for chronic respiratory diseases, such as cystic fibrosis (CF). Progress in CF clinical setting using the lipidic formulation GL67A has demonstrated the relevance of such a strategy while emphasizin...