Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation

• Main Authors: Yun-zi Liu (Author), Ming-yuan Xu (Author), Xiao-yu Dai (Author), Lang Yan (Author), Lei Li (Author), Rui-zhen Zhu (Author), Li-jun Ren (Author), Ji- (Author), Xiao-fang Zhang (Author), Jin-feng Li (Author), Yi-jun Tian (Author), Wen-jing Shi (Author), Ye-qiang Liu (Author), Chun-lei Jiang (Author), Jiang-bo Zhu (Author), Ji-kuai Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in cell proliferation, which is a rate-limiting enzyme that regulates the final step of glycolysis. However, how PKM2 regulates cell meta...