Low-dose Olaparib improves septic cardiac function by reducing ferroptosis via accelerated mitophagy flux

• Main Authors: Ruixue Liu (Author), Fengjuan Li (Author), Shuai Hao (Author), Dongyao Hou (Author), Xue Zeng (Author), He Huang (Author), Gautam Sethi (Author), Jun Guo (Author), Chenyang Duan (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis is a dysregulated response to infection that can result in life-threatening organ failure, and septic cardiomyopathy is a serious complication involving ferroptosis. Olaparib, a classic targeted drug used in oncology, has demonstrated potential protective effects against sepsis. However, the...