Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors

• Main Authors: Fatih Sonmez (Author), Belma Zengin Kurt (Author), Isil Gazioglu (Author), Livia Basile (Author), Aydan Dag (Author), Valentina Cappello (Author), Tiziana Ginex (Author), Mustafa Kucukislamoglu (Author), Salvatore Guccione (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC50 value of 43 nM...