The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac-Induced Acute Renal Injury: Contribution of the Nrf2 Redox-Sensitive Pathway

• Main Authors: Allan J. C. Bussmann (Author), Tiago H. Zaninelli (Author), Telma Saraiva-Santos (Author), Victor Fattori (Author), Carla F. S. Guazelli (Author), Mariana M. Bertozzi (Author), Ketlem C. Andrade (Author), Camila R. Ferraz (Author), Doumit Camilios-Neto (Author), Antônio M. B. Casella (Author), Rubia Casagrande (Author), Sergio M. Borghi (Author), Waldiceu A. Verri (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hesperidin is derived from citrus fruits among other plants. Hesperidin was methylated to increase its solubility, generating hesperidin methyl chalcone (HMC), an emerging flavonoid that possess anti-inflammatory and antioxidant properties. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a...