Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs

• Main Authors: Tatsuki Mochizuki (Author), Yasunori Aoki (Author), Takashi Yoshikado (Author), Kenta Yoshida (Author), Yurong Lai (Author), Hideki Hirabayashi (Author), Yoshiyuki Yamaura (Author), Kevin Rockich (Author), Kunal Taskar (Author), Tadayuki Takashima (Author), Xiaoyan Chu (Author), Maciej J. Zamek‐Gliszczynski (Author), Jialin Mao (Author), Kazuya Maeda (Author), Kenichi Furihata (Author), Yuichi Sugiyama (Author), Hiroyuki Kusuhara (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The accurate prediction of OATP1B‐mediated drug-drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subjects who received oral doses of cyclosporin A (CysA; 20 a...