Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

• Main Authors: Abdallah E. Abdallah (Author), Reda R. Mabrouk (Author), Maged Mohammed Saleh Al Ward (Author), Sally I. Eissa (Author), Eslam B. Elkaeed (Author), Ahmed B. M. Mehany (Author), Mariam A. Abo-Saif (Author), Ola A. El-Feky (Author), Mohamed S. Alesawy (Author), Mohamed Ayman El-Zahabi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared to 54.00 nM for sorafenib. Compounds 15a, 15b, and...