Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis

Tetramethylpyrazine (TMP) is a traditional Chinese herbal medicine with strong anti-inflammatory and cartilage protection activities, and thus a promising candidate for treating osteoarthritis. However, TMP is rapidly cleared from the joint cavity after intra-articular injection and requires multipl...

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Main Authors: Xiuping Zhang (Author), Yang Shi (Author), Zhiyue Zhang (Author), Zhenlei Yang (Author), Guihua Huang (Author)
Format: Book
Published: Elsevier, 2018-05-01T00:00:00Z.
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