Identification of the Major Degradation Pathways of Selumetinib

• Main Authors: Tahar Sif eddine Bouchema (Author), Maxime Annereau (Author), Victoire Vieillard (Author), Raphael Boquet (Author), Gisele Abreu Coelho (Author), Florence Castelli (Author), Audrey Solgadi (Author), Muriel Paul (Author), Najet Yagoubi (Author), Philippe-Henri Secretan (Author), Bernard Do (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selumetinib is administered orally in capsule form and is indicated for the treatment of neurofibromatosis. To facilitate dosage adjustments, liquid preparations, such as solutions or suspensions, are to be developed. This led, first, to determine the stability profile of soluble or dispersed selume...