Effect of obesity and serum leptin level on clopidogrel resistance

• Main Authors: Ali Dogan (Author), Serkan Kahraman (Author), Emrah Usta (Author), Emrah Ozdemir (Author), Uzay Gormus (Author), Cavlan Ciftci (Author)
• Format: Book
• Published: KARE Publishing, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Clopidogrel inhibits platelet aggregation by blockade of platelet adenosine diphosphate (ADP) P2Y12 receptor. Leptin is the obesity gene product, and its serum level increases with obesity. Platelets have leptin receptors on their surfaces. Hyperleptinemia may induce ADP-mediated platelet...