Determination of metabolite of nicergoline in human plasma by high-performance liquid chromatography and its application in pharmacokinetic studies

• Main Authors: Rong Zheng (Author), Yi-Hong Wu (Author), De-Xi Jiang (Author), Dan Zhang (Author)
• Format: Book
• Published: Elsevier, 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A fast, simple and sensitive high performance liquid chromatographic (HPLC) method has been developed for determination of 10α-methoxy-6-methyl ergoline-8β-methanol (MDL, a main metabolite of nicergoline) in human plasma. One-step liquidâliquid extraction (LLE) with diethyl ether was employed as t...