Antimicrobial Activity of Nitrogen-Containing 5-α-Androstane Derivatives: In Silico and Experimental Studies

• Main Authors: Lela Amiranashvili (Author), Nanuli Nadaraia (Author), Maia Merlani (Author), Charalampos Kamoutsis (Author), Anthi Petrou (Author), Athina Geronikaki (Author), Pavel Pogodin (Author), Dmitry Druzhilovskiy (Author), Vladimir Poroikov (Author), Ana Ciric (Author), Jasmina Glamočlija (Author), Marina Sokovic (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated the antimicrobial activity of thirty-one nitrogen-containing 5-α-androstane derivatives in silico using computer program PASS (Prediction of Activity Spectra for Substances) and freely available PASS-based web applications (such as Way2Drug). Antibacterial activity was predicted for 27...