Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified in postmortem tissue: intracellular RNA foci and...

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Main Authors: Saul Herranz-Martin (Author), Jayanth Chandran (Author), Katherine Lewis (Author), Padraig Mulcahy (Author), Adrian Higginbottom (Author), Callum Walker (Author), Isabel Martinez-Pena y Valenzuela (Author), Ross A. Jones (Author), Ian Coldicott (Author), Tommaso Iannitti (Author), Mohammed Akaaboune (Author), Sherif F. El-Khamisy (Author), Thomas H. Gillingwater (Author), Pamela J. Shaw (Author), Mimoun Azzouz (Author)
Format: Book
Published: The Company of Biologists, 2017-07-01T00:00:00Z.
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