Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

• मुख्य लेखकों: Paula Martínez de Iturrate (लेखक), Victor Sebastián-Pérez (लेखक), Montserrat Nácher-Vázquez (लेखक), Catherine S. Tremper (लेखक), Despina Smirlis (लेखक), Julio Martín (लेखक), Ana Martínez (लेखक), Nuria E. Campillo (लेखक), Luis Rivas (लेखक), Carmen Gil (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β inhibitors, as well as from...