Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

• Main Authors: Paula Martínez de Iturrate (Author), Victor Sebastián-Pérez (Author), Montserrat Nácher-Vázquez (Author), Catherine S. Tremper (Author), Despina Smirlis (Author), Julio Martín (Author), Ana Martínez (Author), Nuria E. Campillo (Author), Luis Rivas (Author), Carmen Gil (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania. This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β inhibitors, as well as from...