Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells

• Main Authors: Juwon Lee (Author), Suin Jang (Author), Jihye Im (Author), Youngjin Han (Author), Soochi Kim (Author), HyunA Jo (Author), Wenyu Wang (Author), Untack Cho (Author), Se Ik Kim (Author), Aeran Seol (Author), Boyun Kim (Author), Yong Sang Song (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ovarian cancer is a leading cause of death among gynecologic tumors, often detected at advanced stages. Metabolic reprogramming and increased lipid biosynthesis are key factors driving cancer cell growth. Stearoyl-CoA desaturase 1 (SCD1) is a crucial enzyme involved in de novo lipid synthes...