Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment

• Main Authors: Paula Aranda-Martínez (Author), José Fernández-Martínez (Author), Yolanda Ramírez-Casas (Author), César Rodríguez-Santana (Author), Iryna Rusanova (Author), Germaine Escames (Author), Darío Acuña-Castroviejo (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Beyond sleep/wake, clock genes regulate the daily rhythms of melatonin production, motor activity, innate immunity, and mitochondrial dynamics, among others. All these rhythms are affected in Parkinson's disease (PD), suggesting that chronodisruption may be an early stage of the disease. The ai...