SGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway

• Autores principales: Ruixue Guo (Autor), Peipei Wang (Autor), Xuejun Zheng (Autor), Wen Cui (Autor), Jin Shang (Autor), Zhanzheng Zhao (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Loss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium-glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progre...