SGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway

• Hoofdauteurs: Ruixue Guo (Auteur), Peipei Wang (Auteur), Xuejun Zheng (Auteur), Wen Cui (Auteur), Jin Shang (Auteur), Zhanzheng Zhao (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Loss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium-glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progre...