Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia

• Main Authors: Mary Isabel O'Dea (Author), Lynne Kelly (Author), Ellen McKenna (Author), Ashanty M. Melo (Author), Megan Ni Bhroin (Author), Tim Hurley (Author), Angela T. Byrne (Author), Gabrielle Colleran (Author), Claudine Vavasseur (Author), Afif El-Khuffash (Author), Jan Miletin (Author), John Murphy (Author), Fionnuala Hickey (Author), Eleanor J. Molloy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neonatal encephalopathy (NE) is a significant cause of morbidity and mortality. Persistent inflammation and activation of leukocytes mediate brain injury in NE. The standard of care for NE, therapeutic hypothermia (TH), does not improve outcomes in nearly half of moderate to severe cases, resulting...