Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor

• Hauptverfasser: Linjing Mu (Verfasst von), Roger Slavik (Verfasst von), Adrienne Müller (Verfasst von), Kasim Popaj (Verfasst von), Stjepko Čermak (Verfasst von), Markus Weber (Verfasst von), Roger Schibli (Verfasst von), Stefanie D. Krämer (Verfasst von), Simon M. Ametamey (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2014-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Cannabinoid receptor subtype 2 (CB2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's disease. The CB2 receptor is therefor...