The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P-Receptor Functions Expressed in Xenopus Oocytes

Tramadol has been widely used as analgesic. O-Desmethyl tramadol (ODT) is one of the main metabolites of tramadol, having much greater analgesic potency than tramadol itself. Substance P receptors (SPR) are well known to modulate nociceptive transmission within the spinal cord. In this study, we inv...

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Autori principali: Kouichiro Minami (Autore), Toru Yokoyama (Autore), Junichi Ogata (Autore), Yasuhito Uezono (Autore)
Natura: Libro
Pubblicazione: Elsevier, 2011-01-01T00:00:00Z.
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