The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P-Receptor Functions Expressed in Xenopus Oocytes

• मुख्य लेखकों: Kouichiro Minami (लेखक), Toru Yokoyama (लेखक), Junichi Ogata (लेखक), Yasuhito Uezono (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2011-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Tramadol has been widely used as analgesic. O-Desmethyl tramadol (ODT) is one of the main metabolites of tramadol, having much greater analgesic potency than tramadol itself. Substance P receptors (SPR) are well known to modulate nociceptive transmission within the spinal cord. In this study, we inv...