Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits

• Main Authors: Jinghui Li (Author), Tianjing Zhao (Author), Dailu Guan (Author), Zhangyuan Pan (Author), Zhonghao Bai (Author), Jinyan Teng (Author), Zhe Zhang (Author), Zhili Zheng (Author), Jian Zeng (Author), Huaijun Zhou (Author), Lingzhao Fang (Author), Hao Cheng (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Assessment of genomic conservation between humans and pigs at the functional level can improve the potential of pigs as a human biomedical model. To address this, we developed a deep learning-based approach to learn the genomic conservation at the functional level (DeepGCF) between species...