Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits

• المؤلفون الرئيسيون: Jinghui Li (مؤلف), Tianjing Zhao (مؤلف), Dailu Guan (مؤلف), Zhangyuan Pan (مؤلف), Zhonghao Bai (مؤلف), Jinyan Teng (مؤلف), Zhe Zhang (مؤلف), Zhili Zheng (مؤلف), Jian Zeng (مؤلف), Huaijun Zhou (مؤلف), Lingzhao Fang (مؤلف), Hao Cheng (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Summary: Assessment of genomic conservation between humans and pigs at the functional level can improve the potential of pigs as a human biomedical model. To address this, we developed a deep learning-based approach to learn the genomic conservation at the functional level (DeepGCF) between species...