Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis

• Main Authors: Gulisaina Qiaerxie (Author), Yujia Jiang (Author), Gege Li (Author), Zhixin Yang (Author), Feng Long (Author), Yunzhou Yu (Author), Jian Sheng Lu (Author), Peng Du (Author), Yong Cui (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among all natural and synthetic toxins, botulinum neurotoxins (BoNTs), produced by Clostridium botulinum in an anaerobic environment, are the most toxic polymer proteins. Currently, the most effective modalities for botulism prevention and treatment are vaccination and antitoxin use, respectively. H...