A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

• Main Authors: Shuo Wang (Author), Peter Bartels (Author), Cong Zhao (Author), Arsalan Yousuf (Author), Zhuguo Liu (Author), Shuo Yu (Author), Anuja R. Bony (Author), Xiaoli Ma (Author), Qin Dai (Author), Ting Sun (Author), Na Liu (Author), Mengke Yang (Author), Rilei Yu (Author), Weihong Du (Author), David J. Adams (Author), Qiuyun Dai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuronal nicotinic acetylcholine receptor (nAChR) subtype...