Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice

• Main Authors: Chunxian Zhang (Author), Michael P. Sherman (Author), Lawrence S. Prince (Author), David Bader (Author), Jörn-Hendrik Weitkamp (Author), James C. Slaughter (Author), Steven J. McElroy (Author)
• Format: Book
• Published: The Company of Biologists, 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent inflammation and tissue necrosis. Normally, Paneth...