What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials?

• প্রধান লেখক: Rachael Lawrance (লেখক), Evgeny Degtyarev (লেখক), Philip Griffiths (লেখক), Peter Trask (লেখক), Helen Lau (লেখক), Denise D'Alessio (লেখক), Ingolf Griebsch (লেখক), Gudrun Wallenstein (লেখক), Kim Cocks (লেখক), Kaspar Rufibach (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: SpringerOpen, 2020-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Background Published in 2019, a new addendum to the ICH E9 guideline presents the estimand framework as a systematic approach to ensure alignment among clinical trial objectives, trial execution/conduct, statistical analyses, and interpretation of results. The use of the estimand framework...