What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials?

• Main Authors: Rachael Lawrance (Author), Evgeny Degtyarev (Author), Philip Griffiths (Author), Peter Trask (Author), Helen Lau (Author), Denise D'Alessio (Author), Ingolf Griebsch (Author), Gudrun Wallenstein (Author), Kim Cocks (Author), Kaspar Rufibach (Author)
• Format: Book
• Published: SpringerOpen, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Published in 2019, a new addendum to the ICH E9 guideline presents the estimand framework as a systematic approach to ensure alignment among clinical trial objectives, trial execution/conduct, statistical analyses, and interpretation of results. The use of the estimand framework...