Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

• Main Authors: Sirous Zeinali (Author), Leila Youssefian (Author), Hassan Vahidnezhad (Author), Amir Hossein Saeidian (Author), Soheila Sotoudeh (Author), Hamideh Bagherian (Author), Jouni Uitto (Author)
• Format: Book
• Published: Wolters Kluwer Health, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach. In this study, we perform genome-wide s...