A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy

• Main Authors: Yu Guan (Author), Daisuke Nakano (Author), Yifan Zhang (Author), Lei Li (Author), Wenhua Liu (Author), Motohiro Nishida (Author), Takashige Kuwabara (Author), Asahiro Morishita (Author), Hirofumi Hitomi (Author), Kiyoshi Mori (Author), Masashi Mukoyama (Author), Tsutomu Masaki (Author), Katsuya Hirano (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The kidney expresses protease-activated receptor-1 (PAR-1). PAR-1 is known as a thrombin receptor, but its role in kidney injury is not well understood. In this study, we examined the contribution of PAR-1 to kidney glomerular injury and the effects of its inhibition on development of nephropathy. M...