Population Pharmacokinetic Modeling for Twice-Daily Intravenous Busulfan in a Large Cohort of Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation-A 10-Year Single-Center Experience

Population Pharmacokinetic Modeling for Twice-Daily Intravenous Busulfan in a Large Cohort of Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation-A 10-Year Single-Center Experience

Reaching target exposure of busulfan-based conditioning prior to hematopoietic stem cell transplantation is vital for favorable therapy outcomes. Yet, a wide inter-patient and inter-occasion variability in busulfan exposure has been reported, especially in children. We aimed to identify factors asso...

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Main Authors: Katharina M. Schreib (Author), Dominic S. Bräm (Author), Ulrike Barbara Zeilhofer (Author), Daniel Müller (Author), Tayfun Güngör (Author), Stefanie D. Krämer (Author), Mathias M. Hauri-Hohl (Author)
Format: Book
Published: MDPI AG, 2023-12-01T00:00:00Z.
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