Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhibitors based on the structural optimisation of pre...

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Main Authors: Daseul Im (Author), Joonhong Jun (Author), Jihyun Baek (Author), Haejin Kim (Author), Dahyun Kang (Author), Hyunah Bae (Author), Hyunwook Cho (Author), Jung-Mi Hah (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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