NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation

• Main Authors: Timothy Hamerly (Author), Rebecca E. Tweedell (Author), Bernadette Hritzo (Author), Vincent O. Nyasembe (Author), Babu L. Tekwani (Author), N. P. Dhammika Nanayakkara (Author), Larry A. Walker (Author), Rhoel R. Dinglasan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Malaria is a major global health threat, with nearly half the world's population at risk of infection. Given the recently described delayed clearance of parasites by artemisinin-combined therapies, new antimalarials are needed to facilitate the global effort toward elimination and eradication....