Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures

• Egile Nagusiak: Bergstrom Carl T (Egilea), Lipsitch Marc (Egilea), Antia Rustom (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2003-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resi...