Evaluation of Solubility, Dissolution Rate, and Oral Bioavailability of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin as Inclusion Complexes of the Tyrosine Kinase Inhibitor, Alectinib

Evaluation of Solubility, Dissolution Rate, and Oral Bioavailability of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin as Inclusion Complexes of the Tyrosine Kinase Inhibitor, Alectinib

This study aims to improve the solubility and dissolution rate of alectinib (ALB), a tyrosine kinase inhibitor commonly used for treating non-small-cell carcinoma (NSCLC). Given ALB's low solubility and bioavailability, complexation with β-cyclodextrin (βCD) and hydroxy propyl β-cyclodextrin (H...

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Main Authors: Bashar J. M. Majeed (Author), Mohammed A. Saadallah (Author), Israa H. Al-Ani (Author), Mohamed K. El-Tanani (Author), Khaldun M. Al Azzam (Author), Hassan H. Abdallah (Author), Feras Al-Hajji (Author)
Format: Book
Published: MDPI AG, 2024-06-01T00:00:00Z.
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