Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation

• Prif Awduron: Francesco Di Virgilio (Awdur), Anna L. Giuliani (Awdur), Valentina Vultaggio-Poma (Awdur), Simonetta Falzoni (Awdur), Alba C. Sarti (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The P2X7 receptor (P2X7R) is a ligand-gated plasma membrane ion channel belonging to the P2X receptor subfamily activated by extracellular nucleotides. General consensus holds that the physiological (and maybe the only) agonist is ATP. However, scattered evidence generated over the last several year...