Polysaccharide Hydrogels Support the Long-Term Viability of Encapsulated Human Mesenchymal Stem Cells and Their Ability to Secrete Immunomodulatory Factors

• Main Authors: Fahd Hached (Author), Claire Vinatier (Author), Pierre-Gabriel Pinta (Author), Philippe Hulin (Author), Catherine Le Visage (Author), Pierre Weiss (Author), Jérôme Guicheux (Author), Aurélie Billon-Chabaud (Author), Gaël Grimandi (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While therapeutically interesting, the injection of MSCs suffers major limitations including cell death upon injection and a massive leakage outside the injection site. We proposed to entrap MSCs within spherical particles derived from alginate, as a control, or from silanized hydroxypropyl methylce...