Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine.

• Main Authors: Alexander B Taylor (Author), Livia Pica-Mattoccia (Author), Chiara M Polcaro (Author), Enrica Donati (Author), Xiaohang Cao (Author), Annalisa Basso (Author), Alessandra Guidi (Author), Anastasia R Rugel (Author), Stephen P Holloway (Author), Timothy J C Anderson (Author), P John Hart (Author), Donato Cioli (Author), Philip T LoVerde (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. mansoni sulfotransferase (SmSULT) was identified as the target of OXA act...