Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

• Main Authors: Zheng-Wei Zhang (Author), Lin Cong (Author), Ran Peng (Author), Pei Han (Author), Shu-Rong Ma (Author), Li-Bin Pan (Author), Jie Fu (Author), Hang Yu (Author), Yan Wang (Author), Jian-Dong Jiang (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota. This study focused on the CYP51 enzyme of intestinal bact...