Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells

• المؤلفون الرئيسيون: Kwan-Woo Kim (مؤلف), Hye Jin Kim (مؤلف), Jae Hak Sohn (مؤلف), Joung Han Yim (مؤلف), Youn-Chul Kim (مؤلف), Hyuncheol Oh (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2020-07-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

In the course of our continuous investigation on the bioactive marine-derived fungal metabolites, terrein was isolated from marine-derived fungal strain Penicillium sp. SF-7181. Terrein inhibited the overproduction of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2),...