Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

• المؤلفون الرئيسيون: Il-Je Cho (مؤلف), Doyeon Kim (مؤلف), Eun-Ok Kim (مؤلف), Kyung-Hwan Jegal (مؤلف), Jae-Kwang Kim (مؤلف), Sang-Mi Park (مؤلف), Rongjie Zhao (مؤلف), Sung-Hwan Ki (مؤلف), Sang-Chan Kim (مؤلف), Sae-Kwang Ku (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2021-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Ferroptosis is a type of programmed necrosis triggered by iron-dependent lipid peroxidation. We investigated the role of B-cell translocation gene 1 (BTG1) in cystine and methionine deficiency (CST/Met (−))-mediated cell death. CST/Met (−) depleted reduced and oxidized glutathione in hepatocyte-deri...