Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1

• Main Authors: Il-Je Cho (Author), Doyeon Kim (Author), Eun-Ok Kim (Author), Kyung-Hwan Jegal (Author), Jae-Kwang Kim (Author), Sang-Mi Park (Author), Rongjie Zhao (Author), Sung-Hwan Ki (Author), Sang-Chan Kim (Author), Sae-Kwang Ku (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferroptosis is a type of programmed necrosis triggered by iron-dependent lipid peroxidation. We investigated the role of B-cell translocation gene 1 (BTG1) in cystine and methionine deficiency (CST/Met (−))-mediated cell death. CST/Met (−) depleted reduced and oxidized glutathione in hepatocyte-deri...