Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model

• প্রধান লেখক: Hiroko Izumi-Nakaseko (লেখক), Yuji Nakamura (লেখক), Xin Cao (লেখক), Takeshi Wada (লেখক), Kentaro Ando (লেখক), Atsushi Sugiyama (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2016-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Since astemizole in an oral dose of 50 mg/kg/day was recently reported to exert anti-cancer effect in mice, we evaluated its proarrhythmic potential using the atrioventricular block dogs in order to clarify its cardiac safety profile. An oral dose of 3 mg/kg prolonged the QT interval without affecti...