Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome.

• Main Authors: Marisa Oliveira (Author), Worachart Lert-Itthiporn (Author), Bruno Cavadas (Author), Verónica Fernandes (Author), Ampaiwan Chuansumrit (Author), Orlando Anunciação (Author), Isabelle Casademont (Author), Fanny Koeth (Author), Marina Penova (Author), Kanchana Tangnararatchakit (Author), Chiea Chuen Khor (Author), Richard Paul (Author), Prida Malasit (Author), Fumihiko Matsuda (Author), Etienne Simon-Lorière (Author), Prapat Suriyaphol (Author), Luisa Pereira (Author), Anavaj Sakuntabhai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For...