Islet amyloid polypeptide does not suppress pancreatic cancer

• Main Authors: Austin J. Taylor (Author), Evgeniy Panzhinskiy (Author), Paul C. Orban (Author), Francis C. Lynn (Author), David F. Schaeffer (Author), James D. Johnson (Author), Janel L. Kopp (Author), C. Bruce Verchere (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression. IAPP has been reported to act as a tumour-suppressor in p53-deficient cancers capabl...