Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats

• मुख्य लेखकों: Shahinaze A. Fouad (लेखक), Mahmoud H. Teaima (लेखक), Mostafa I. Gebril (लेखक), Fathy I. Abd Allah (लेखक), Mohamed A. El-Nabarawi (लेखक), Sammar Fathy Elhabal (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

AbstractRepaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due to hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed to encapsulate RPG...