Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats

• Main Authors: Shahinaze A. Fouad (Author), Mahmoud H. Teaima (Author), Mostafa I. Gebril (Author), Fathy I. Abd Allah (Author), Mohamed A. El-Nabarawi (Author), Sammar Fathy Elhabal (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractRepaglinide (RPG), a monotherapy insulin secretagogue used to treat diabetes mellitus-type II yet, it suffers from poor water solubility and variable bioavailability (∼ 50%) due to hepatic first pass metabolism. In this study, 2FI I-Optimal statistical design was employed to encapsulate RPG...