High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

• Main Authors: Junzhi Yang (Author), Robert D. Betterton (Author), Erica I. Williams (Author), Joshua A. Stanton (Author), Elizabeth S. Reddell (Author), Chidinma E. Ogbonnaya (Author), Emma Dorn (Author), Thomas P. Davis (Author), Jeffrey J. Lochhead (Author), Patrick T. Ronaldson (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood-brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-administered drugs. To study APAP effects, female Spragu...