High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

• Asıl Yazarlar: Junzhi Yang (Yazar), Robert D. Betterton (Yazar), Erica I. Williams (Yazar), Joshua A. Stanton (Yazar), Elizabeth S. Reddell (Yazar), Chidinma E. Ogbonnaya (Yazar), Emma Dorn (Yazar), Thomas P. Davis (Yazar), Jeffrey J. Lochhead (Yazar), Patrick T. Ronaldson (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood-brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-administered drugs. To study APAP effects, female Spragu...