High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

• मुख्य लेखकों: Junzhi Yang (लेखक), Robert D. Betterton (लेखक), Erica I. Williams (लेखक), Joshua A. Stanton (लेखक), Elizabeth S. Reddell (लेखक), Chidinma E. Ogbonnaya (लेखक), Emma Dorn (लेखक), Thomas P. Davis (लेखक), Jeffrey J. Lochhead (लेखक), Patrick T. Ronaldson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood-brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-administered drugs. To study APAP effects, female Spragu...