Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma

• Main Authors: Yumi Yamamoto (Author), Patricia Sanwald Ducray (Author), Marcus Björnsson (Author), Kevin Smart (Author), Paul Grimsey (Author), Suresh Vatakuti (Author), Agnes Portron (Author), Benoit Massonnet (Author), Daniel A. Norris (Author), Hanna E. Silber Baumann (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tominersen is an intrathecally administered antisense oligonucleotide targeting huntingtin mRNA which leads to a dose‐dependent, reversible lowering of cerebrospinal fluid (CSF) mutant huntingtin protein concentration in individuals with Huntington's disease. Nonlinear mixed‐effect pop...