IBD Subtype-Regulators IFNG and GBP5 Identified by Causal Inference Drive More Intense Innate Immunity and Inflammatory Responses in CD Than Those in UC

• Main Authors: Sheng Gao (Author), Yichen Li (Author), Dingfeng Wu (Author), Na Jiao (Author), Li Yang (Author), Rui Zhao (Author), Zhifeng Xu (Author), Wanning Chen (Author), Xutao Lin (Author), Sijing Cheng (Author), Lixin Zhu (Author), Ping Lan (Author), Ruixin Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The pathological differences between Crohn's disease (CD) and ulcerative colitis (UC) are substantial and unexplained yet. Here, we aimed to identify potential regulators that drive different pathogenesis of CD and UC by causal inference analysis of transcriptome data.Methods: Krusk...