Guanfacine Normalizes the Overexpression of Presynaptic α-2A Adrenoceptor Signaling and Ameliorates Neuropathic Pain in a Chronic Animal Model of Type 1 Diabetes

• Main Authors: Neha Munawar (Author), Joelle Nader (Author), Najat H. Khadadah (Author), Ashraf Al Madhoun (Author), Waleed Al-Ali (Author), Linu A. Varghese (Author), Willias Masocha (Author), Fahd Al-Mulla (Author), Milad S. Bitar (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Diabetes is associated with several complications, including neuropathic pain, which is difficult to manage with currently available drugs. Descending noradrenergic neurons possess antinociceptive activity; however, their involvement in diabetic neuropathic pain remains to be explored. M...